A. Vogel Products
Each ml contains:
Milk Thistle fruit tincture (f) (Silybum marianum)
Alcohol content = 61 % v/v
Adults: take 10 drops in a small amount of water, 3-5 times daily. Salivate
before swallowing. Milk Thistle may be taken for up to 2 months uninterrupted.
Milk Thistle ® 50 ML
Milk Thistle is a magnificent plant with its leaves covered by large white veins
and spots. There is a medieval tradition saying that the milk-white veins of the
leaves come from the milk of the Virgin Mary, which once fell upon a plant of
thistle. Milk Thistle seeds are probably the best liver regenerator and
existence. Their active ingredients are flavones and flavo-lignans, collectively
called silymarin. These molecules have antioxidant and anti-proliferative
effects, some of which are still being discovered.
Actions and pharmacology
A.Vogel’s Milk Thistle extract is prepared with great care. The silky hairs
covering the Milk Thistle fruit are removed so that only the fruit is used in
the tincture. This tincture contains silybin, silydianin, silychristin,
isosilybin, small quantities of silandrin, silymonin and silybinomere, flavonoids like quercetin and taxifolin, phytosterols like sitosterols, and
Milk Thistle’s action mechanisms have not all been elucidated but its
antioxidant(1), anti-inflammatory(2) and anti-proliferative(3) effects are
acknowledged. Although clinically proven, its liver protection effect has not
yet been explained. The German Commission E acknowledges its benefits in cases
of: dyspeptic complaints; toxic liver damage; supportive treatment in chronic
inflammatory liver disease and hepatic cirrhosis.(4)
A study on patients taking a medication for Alzheimer’s disease, Tacrine,
demonstrated that Milk Thistle reduces the gastrointestinal and cholinergic side
effects of the medication.(5)
Milk Thistle’s hepatoprotective effect has been evaluated on Hungarian workers
exposed to industrial solvents containing toluene. After 30 days of treatment
with Milk Thistle, all liver function parameters (blood enzymes) and blood
platelets were significantly improved.(6)
An in vivo study proved silymarin’s ability to reverse the effects of aflatoxin
B1 on the liver cells.(7)
Many reports mention Milk Thistle’s efficacy in the treatment of mushroom
poisoning by death cap (Amanita phalloides). Silybin and silybinin would be
responsible for this effect.(8-9)
contraindications and interactions
Contraindication: known allergy to Milk Thistle. Since Milk Thistle is a member
of the compositaceae (asteraceae) family, cross allergy is possible with flowers
such as daisy, chrysanthemum, echinacea, etc.
Milk Thistle may cause loose stools due to the increase in bile production.
The authors do not agree on Milk Thistle’s safety during pregnancy. Its anti-proliferative
effect motivates the warning. On the other hand, many authors (Hoffmann D,
Provost M, etc.) consider Milk Thistle to be safe during pregnancy and
beneficial during breast-feeding. Caution is advised. Please consult a competent
1-Jiang C, Agarwal R, Lu J. Anti-angiogenic potential of a cancer
chemopreventive flavonoid antioxidant, silymarin: inhibition of key attributes
of vascular endothelial cells and angiogenic cytokine secretion by cancer
epithelial cells. Biochem Biophys Res Commun 2000 Sep 16;276(1):371-8
2-Gupta OP, Sing S, Bani S, Sharma N et al. Anti-inflammatory and anti-arthritic
activities of silymarin acting through inhibition of 5-lipoxygenase.
3-Bhatia N, Agarwal R. Detrimental effect of cancer preventive phytochemicals
silymarin, genistein and epigallocatechin 3-gallate on epigenetic events in
human prostate carcinoma DU145 cells. <>Prostate 2001 Feb 1;46(2):98-107
4-The Complete German Commission E Monographs, Therapeutic Guide to Herbal
Medicines. Blumenthal M et al 1998. American Botanical Council, 6200 Manor Rd,
Austin, Texas, 78723.
5-Allain H, Schuck S, Lebreton S et al. Aminotransferase levels and silymarin in
de novo tacrine-treated patients with Alzheimer's disease. Dement Geriatr Cogn
Disord 1999 May-Jun;10(3):181-5
6-Szilard S, Szentgyorgyi D, Demeter I. Protective effect of Legalon in workers
exposed to organic solvents. Acta Med Hung 1988;45(2):249-56
7-Rastogi R, Srivastava AK, Srivastava M, Rastogi AK. Hepatocurative effect of
picroliv and silymarin against aflatoxin B1 induced hepatotoxicity in rats.
Planta Med 2000 Dec;66(8):709-13
8-Carducci R, Armellino MF, Volpe C et al. Silibinin and acute poisoning with
Amanita phalloides. Minerva Anestesiol 1996 May;62(5):187-93
9-Daoudal P, Noirot A, Wagschal G et al. Traitement des empoisonnements aux
phalloïdes avec la silymarine et le ceftazidime. Presse Med 1989 Sep
10-Natural Medicines Comprehensive DataBase 2001. Pharmacist's Letter 3120 W.
March Lane, PO Box 8190, Stockton, CA 95208. Tel: 1-209-472-2244 (Web site
continually updated. (www.naturaldatabase.com)
have not been evaluated by the Food and Drug Administration.
This product is not meant to diagnose, treat, cure or prevent any disease.
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