Improves digestion by increasing bile secretion. Relieves liver and gall bladder
disorders. Indicated for hepatic insufficiency, jaundice (icterus), constipation
linked with hepatic insufficiency and loss of appetite. Relieves nausea.
Boldocynaraź 50 ML
Each ml contains Tinctures (f) of:
Fresh organic Artichoke herb (Cynara scolymus) (ratio 1:3) 0.467 ml
Milk Thistle fruit (Silybum marianum) (ratio 1:1) 0.319 ml
Fresh wild Dandelion leaves and root (Taraxacum officinalis) (ratio 1:1) 0.12 ml
Boldo leaves (Peumus boldus) (ratio 1:10) 0.07 ml
Other ingredients: Fresh organic peppermint herb tincture (f) (Mentha piperita)
(ratio 1:2) 0.03 ml
Alcohol content = 61% v/v
Adults: take 10-15 drops in a small amount of water, 3 times daily after meals.
Salivate before swallowing.
Fat digestion has always been a source of problems. Thermal cures, clysters
(enemas) and all those treatments answered the need of many engorged livers.
Today, the innumerable food additives, trans fatty acids and fried foods, not to
mention pollutants and stress, compromise liver function. Medicinal herbs like
Artichoke, Boldo, Milk Thistle and Dandelion are a safe and effective response
to this age-old problem.
Actions and pharmacology:
Artichoke (Cynara scolymus)
The well-known effects of Artichoke on the liver are probably due to its
phenolic acids (chlorogenic, caffeic and cynarine), sesquiterpenes, and
flavonoids (scolymoside, cynaroside and luteolin). Artichoke extract relieves
dyspepsia by stimulating bile production and excretion (choleretic and
cholagogue effects). Artichoke is also effective against
hypercholesterolemia.(1) Thanks to the antioxidant effects of the flavonoids,
Artichoke, a bit like Milk Thistle, has very interesting hepatoprotective
properties.(2) This effect was demonstrated against an industrial solvent,
carbon tetrachloride.(3) Traditionally, Artichoke is used as an aperitive, a
depurative and a diuretic.
The German Commission E acknowledges its benefits in cases of: dyspeptic
Milk Thistle (Silybum marianum)
Milk Thistle is probably the most powerful herb for liver detoxification. It
relieves dyspepsia, acts as a hepatoprotective agent and even helps to
regenerate hepatocytes (liver cells) in cases of cirrhosis and hepatitis. Milk
Thistle is also recommended to treat mushroom poisoning by death cap (Amanita
phalloides). It is used to treat liver complaints from loss of appetite to
chronic inflammatory conditions. Its main constituents are flavolignans (silybin,
isosilybin, silychristin and silydianin) collectively known as silymarin. (See
Milk Thistle information sheet)
The German Commission E acknowledges its benefits in cases of: dyspeptic
complaints; toxic liver damage; supportive treatment in chronic inflammatory
liver disease and hepatic cirrhosis.
Dandelion (Taraxacum officinalis)
Dandelion is a very interesting herb for the digestive system. Its root has
cholagogue and depurative properties for the liver. The bitter constituents,
collectively called taraxacins (sometimes eudesmanolides), have a beneficial
effect on slow digestion. Dandelion leaf is one of the best herbal diuretics. It
is also a very good source of carotenes and potassium. The whole herb is used
for loss of appetite, dyspepsia, flatulence and feelings of fullness after
The German Commission E acknowledges its benefits in cases of: disturbances in
bile flow, edema, loss of appetite, and dyspepsia.
Boldo (Peumus boldus)
Boldo is a South American herb used to relieve intestinal cramps, bile flow
problems and cystitis. Boldo has diuretic, sedative (antispasmodic), bile
stimulating and antiseptic effects. Its main constituents are alkaloids
(responsible for the digestive and liver stimulation) and a volatile oil
(responsible for the antiseptic effect).
The German Commission E acknowledges its benefits in cases of: mild spastic
complaints of the gastrointestinal tract and dyspepsia.
Peppermint (Mentha piperita)
In addition to its good taste, peppermint acts as a spasmolytic and carminative
(anti-flatulent) and stimulates the liver functions. It is rich in azulene, a
substance known for its anti-inflammatory and anti-ulcer effects. Its other
components are flavonoids and a volatile oil rich in menthol. Peppermint is
often used to relieve dyspepsia and digestive cramps.
Peppermint is "generally recognized as safe" (GRAS) in the USA, which means that
it is safe at amounts found in food.
The German Commission E acknowledges its benefits in cases of: flatulence;
spastic complaints of the gastrointestinal tract, the gallbladder and bile
In a double blind placebo-controlled study published in 2000, 143 patients with
high cholesterol received either an Artichoke extract or a placebo. Patients
taking the Artichoke extract saw their LDL cholesterol (bad cholesterol) reduced
by 22.9% compared to 6.3% with the placebo. No side effects were reported.(1)
Milk Thistle's regenerative properties have been confirmed by many scientific
studies.(4-5) Milk Thistle helps to control the characteristic auto-intoxication
and hyperinsulinemia of cirrhotic patients. Its hepatoprotective effect has been
evaluated on Hungarian workers exposed to industrial solvents containing
toluene. After 30 days of treatment with Milk Thistle, all liver function
parameters (blood enzymes) and blood platelets were significantly improved.(6)
Precautions, contraindications and interactions:
Contraindication: known allergy to one of the ingredients. Since Artichoke, Milk
Thistle and Dandelion are part of the compositaceae (asteraceae) family, cross
allergy is possible with flowers such as daisy, chrysanthemum, echinacea, etc.
Boldocynaraź is not recommended during pregnancy because of the possible
presence of an alkaloid from Boldo, ascaridole. Its use during breast-feeding is
not recommended. Boldocynaraź may have a slight laxative effect (due to the
increase in bile flow) that can be lessened with a reduction in dosage.
Theoretically, the presence or coumarins in Boldo may interact with blood
Boldocynaraź is contraindicated in the presence of gallstones (obstruction of
bile ducts), colitis, Crohns disease, ileitis, stomach ulcers or hepatitis.
1-Englisch W, Beckers C, Unkauf M et al. Efficacy of Artichoke dry extract in
patients with hyperlipoproteinemia. Arzneimittelforschung 2000 Mar;50(3):260-5.
2-Gebhardt R. Antioxidative and protective properties of extracts from leaves of
the Artichoke (Cynara scolymus L.) against hydroperoxide-induced oxidative
stress in cultured rat hepatocytes. Toxicol Appl Pharmacol 1997;144:279-86.
3-Adzet T,Camarasa J and Laguna JC. Hepatoprotective activity of polyphenolic
compounds from cynara scolymus against CCl4 toxicity in isolated rat hepatocytes.
J Natural Products 1987;50(4):612-7.
4-Velussi M, et al. Long-term (12 months) treatment with an anti-oxidant drug (silymarin)
is effective on hyperinsulinemia, exogenous insulin need and malondialdehyde
levels in cirrhotic diabetic patients. J Hepatol, 1997; 26: 871-79.
5-Salmi HA, Sarna S. "Effect of silymarin on chemical, functional, and
morphological alterations of the liver. A double-blind controlled study." Scand
J Gastroenterol, 1982; 17: 517-21.
6-Szilard S, Szentgyorgyi D, Demeter I. Protective effect of Legalon (Milk
Thistle extract) in workers exposed to organic solvants. Acta med Hung
7-The Complete German Commission E Monographs, Therapeutic Guide to Herbal
Medicines. Blumenthal M et al 1998. American Botanical Council, 6200 Manor Rd,
Austin, Texas, 78723.
8-Natural Medicines Comprehensive DataBase 2001. Pharmacist's Letter 3120 W.
March Lane, PO Box 8190, Stockton, CA 95208
have not been evaluated by the Food and Drug Administration.
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